Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility.
Identifieur interne : 000694 ( 2020/Analysis ); précédent : 000693; suivant : 000695Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility.
Auteurs : Hong-Long Ji [États-Unis] ; Runzhen Zhao [États-Unis] ; Sadis Matalon [États-Unis] ; Michael A. Matthay [États-Unis]Source :
- Physiological reviews [ 1522-1210 ] ; 2020.
Descripteurs français
- KwdFr :
- Comorbidité, Facteurs de risque, Fibrinolysine (métabolisme), Humains, Infections à coronavirus (mortalité), Infections à coronavirus (physiopathologie), Infections à coronavirus (sang), Infections à coronavirus (épidémiologie), Interactions hôte-pathogène (physiologie), Pandémies, Plasminogène (métabolisme), Pneumopathie virale (mortalité), Pneumopathie virale (physiopathologie), Pneumopathie virale (sang), Pneumopathie virale (épidémiologie), Susceptibilité à une maladie (sang), Syndrome de détresse respiratoire de l'adulte (physiopathologie), Syndrome de détresse respiratoire de l'adulte (sang), Syndrome de détresse respiratoire de l'adulte (virologie).
- MESH :
- mortalité : Infections à coronavirus, Pneumopathie virale.
- métabolisme : Fibrinolysine, Plasminogène.
- physiologie : Interactions hôte-pathogène.
- physiopathologie : Infections à coronavirus, Pneumopathie virale, Syndrome de détresse respiratoire de l'adulte.
- sang : Infections à coronavirus, Pneumopathie virale, Susceptibilité à une maladie, Syndrome de détresse respiratoire de l'adulte.
- virologie : Syndrome de détresse respiratoire de l'adulte.
- épidémiologie : Infections à coronavirus, Pneumopathie virale.
- Comorbidité, Facteurs de risque, Humains, Pandémies.
English descriptors
- KwdEn :
- Betacoronavirus (metabolism), Betacoronavirus (pathogenicity), Comorbidity, Coronavirus Infections (blood), Coronavirus Infections (epidemiology), Coronavirus Infections (mortality), Coronavirus Infections (physiopathology), Disease Susceptibility (blood), Fibrinolysin (metabolism), Host-Pathogen Interactions (physiology), Humans, Pandemics, Plasminogen (metabolism), Pneumonia, Viral (blood), Pneumonia, Viral (epidemiology), Pneumonia, Viral (mortality), Pneumonia, Viral (physiopathology), Respiratory Distress Syndrome, Adult (blood), Respiratory Distress Syndrome, Adult (physiopathology), Respiratory Distress Syndrome, Adult (virology), Risk Factors.
- MESH :
- chemical , metabolism : Fibrinolysin, Plasminogen.
- blood : Coronavirus Infections, Disease Susceptibility, Pneumonia, Viral, Respiratory Distress Syndrome, Adult.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- metabolism : Betacoronavirus.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- pathogenicity : Betacoronavirus.
- physiology : Host-Pathogen Interactions.
- physiopathology : Coronavirus Infections, Pneumonia, Viral, Respiratory Distress Syndrome, Adult.
- virology : Respiratory Distress Syndrome, Adult.
- Comorbidity, Humans, Pandemics, Risk Factors.
Abstract
Patients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, chronic obstructive pulmonary disease, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyperfibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19.
DOI: 10.1152/physrev.00013.2020
PubMed: 32216698
Affiliations:
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pubmed:32216698Le document en format XML
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Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Zhao, Runzhen" sort="Zhao, Runzhen" uniqKey="Zhao R" first="Runzhen" last="Zhao">Runzhen Zhao</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Matalon, Sadis" sort="Matalon, Sadis" uniqKey="Matalon S" first="Sadis" last="Matalon">Sadis Matalon</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Cellular and Molecular Biology, University of Texas Health Science Centre at Tyler, Tyler, Texas; Texas Lung Injury Institute, University of Texas Health Science Centre at Tyler, Tyler, Texas; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Matthay, Michael A" sort="Matthay, Michael A" uniqKey="Matthay M" first="Michael A" last="Matthay">Michael A. 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of Molecular and Translational Biomedicine, Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and Department of Medicine and Anesthesia, University of California San Francisco, San Francisco</wicri:cityArea></affiliation></author></analytic><series><title level="j">Physiological reviews</title><idno type="eISSN">1522-1210</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus (metabolism)</term><term>Betacoronavirus (pathogenicity)</term><term>Comorbidity</term><term>Coronavirus Infections (blood)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (physiopathology)</term><term>Disease Susceptibility (blood)</term><term>Fibrinolysin (metabolism)</term><term>Host-Pathogen Interactions (physiology)</term><term>Humans</term><term>Pandemics</term><term>Plasminogen (metabolism)</term><term>Pneumonia, Viral (blood)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (physiopathology)</term><term>Respiratory Distress Syndrome, Adult (blood)</term><term>Respiratory Distress Syndrome, Adult (physiopathology)</term><term>Respiratory Distress Syndrome, Adult (virology)</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Comorbidité</term><term>Facteurs de risque</term><term>Fibrinolysine (métabolisme)</term><term>Humains</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (physiopathologie)</term><term>Infections à coronavirus (sang)</term><term>Infections à coronavirus (épidémiologie)</term><term>Interactions hôte-pathogène (physiologie)</term><term>Pandémies</term><term>Plasminogène (métabolisme)</term><term>Pneumopathie virale (mortalité)</term><term>Pneumopathie virale (physiopathologie)</term><term>Pneumopathie virale (sang)</term><term>Pneumopathie virale (épidémiologie)</term><term>Susceptibilité à une maladie (sang)</term><term>Syndrome de détresse respiratoire de l'adulte (physiopathologie)</term><term>Syndrome de détresse respiratoire de l'adulte (sang)</term><term>Syndrome de détresse respiratoire de l'adulte (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fibrinolysin</term><term>Plasminogen</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term><term>Disease Susceptibility</term><term>Pneumonia, Viral</term><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Fibrinolysine</term><term>Plasminogène</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Interactions hôte-pathogène</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Host-Pathogen Interactions</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Susceptibilité à une maladie</term><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome de détresse respiratoire de l'adulte</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Comorbidity</term><term>Humans</term><term>Pandemics</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Comorbidité</term><term>Facteurs de risque</term><term>Humains</term><term>Pandémies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, chronic obstructive pulmonary disease, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyperfibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Ji, Hong Long" sort="Ji, Hong Long" uniqKey="Ji H" first="Hong-Long" last="Ji">Hong-Long Ji</name></region><name sortKey="Matalon, Sadis" sort="Matalon, Sadis" uniqKey="Matalon S" first="Sadis" last="Matalon">Sadis Matalon</name><name sortKey="Matthay, Michael A" sort="Matthay, Michael A" uniqKey="Matthay M" first="Michael A" last="Matthay">Michael A. Matthay</name><name sortKey="Zhao, Runzhen" sort="Zhao, Runzhen" uniqKey="Zhao R" first="Runzhen" last="Zhao">Runzhen Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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